Hydroxyzine is a first-generation antihistamine of the diphenylmethane and piperazine class. It was first synthesized by Union Chimique Belge in 1956 and was.
Studies have also been conducted which show that long-term prescription of hydroxyzine can lead to tardive dyskinesia after years of use, but effects related to dyskinesia have also anecdotally been reported after periods of 7.5 months, such as continual head rolling, lip licking and other forms of athetoid movement. In certain cases, elderly patients' previous interactions with phenothiazine derivatives or pre-existing neuroleptic treatment may have had some contribution towards dyskinesia at the administration of hydroxyzine due to hypersensitivity caused due to the prolonged treatment, and therefore some contraindication is given to the short-term administration of hydroxyzine to those with previous phenothiazine use.
Hydroxyzine's predominant mechanism of action is as a potent H 1 receptor inverse agonist (K i = 2 nM).
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Hydroxyzine reduces activity in the central nervous system. It also acts as an antihistamine that reduces the effects of natural chemical.
Allergies Vistaril, levocetirizine, Xyzal, Atarax, doxylamine, Acthar, More.
-Oral: 50 to 100 mg orally -IM: 25 to 100 mg Uses: -Oral: As a sedative when used as premedication and following general anesthesia.
4 days ago C21H27CIN202•2HCI M.W. 447.83. Hydroxyzine hydrochloride occurs as a white, odorless powder which is very soluble in water. Hydroxyzine.
Hydroxyzine hydrochloride is not a cortical depressant, but its action may be due to a suppression of activity in certain key regions of the subcortical area of the central nervous system. Hydroxyzine hydrochloride is unrelated chemically to the phenothiazines, reserpine, meprobamate, or the benzodiazepines.
For symptomatic relief of anxiety and tension associated with psychoneurosis and as an adjunct in organic disease states in which anxiety is manifested: in adults, 50-100 mg q.i.d.; children under 6 years, 50 mg daily in divided doses and over 6 years, 50-100 mg daily in divided doses.
Atropine and other belladonna alkaloids are not affected by the drug.
Learn about the potential side effects of hydroxyzine. Includes common and rare side effects information for consumers and healthcare professionals.
Frequency not reported: Thickened respiratory tract secretions, wheezing, nasal stuffiness, throat dryness Postmarketing reports: Bronchospasm.
Frequency not reported: Liver dysfunction Postmarketing reports: Abnormal liver function tests.
Other brands: Vistaril, Atarax, Hyzine.
Postmarketing reports: Accommodation disorder, blurred vision.
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Frequency not reported: Palpitations, flushing, chest tightness Postmarketing reports: QT interval prolongation, Torsade de Pointes and other ventricular arrhythmias, tachycardia, hypotension.
Some of the side effects that can occur with hydroxyzine may not need medical attention.