(desipramine hydrochloride) Tablets, USP. Suicidality and Antidepressant Drugs. Antidepressants increased the risk compared to placebo of.
NORPRAMIN is indicated for the treatment of depression.
There has been a report of an “acute collapse” and “sudden death” in an 8-year-old (18 kg) male, treated for 2 years for hyperactivity.
Depression and certain other psychiatric disorders are themselves associated with increases in the risk of suicide. Short-term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults beyond age 24; there was a reduction in risk with antidepressants compared to placebo in adults aged 65 and older.
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The risk of serotonin syndrome/toxicity may be more likely when you start or increase the dose of these drugs.
Easy to read patient leaflet for desipramine. Includes indications, proper use, special instructions, precautions, and possible side effects.
Some MEDICINES MAY INTERACT with desipramine. l your health care provider if you are taking any other medicines, especially any of the following:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Treating depression. It may be also be used for other conditions as determined by your doctor.
Depression trazodone, sertraline, Xanax, citalopram, Lexapro, Zoloft, Cymbalta, Prozac, Celexa, Wellbutrin, alprazolam, fluoxetine, amitriptyline, bupropion, duloxetine, venlaine, escitalopram, mirtazapine, paroxetine, quetiapine, Paxil, Effexor, Abilify, Remeron, nortriptyline, More.
Desipramine is a tricyclic antidepressant.
Desipramine hydrochloride is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic.
2-hydroxydesipramine is thought to retain some amine reuptake inhibition and may possess cardiac depressant activity. The 2-hydroxylation metabolic pathway of desipramine is under genetic control. Desipramine is extensively metabolized in the liver by CYP2D6 (major) and CYP1A2 (minor) to 2-hydroxydesipramine, an active metabolite.
7-60+ hours; 70% eliminated renally.
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Desipramine also possesses minor anticholinergic activity, through its affinity for muscarinic receptors.
Information on the drug desipramine (Norpramin) prescribed for the treatment of depression. Off label uses include the treatment of panic attacks, bulimia.
He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Treatment for IBS includes diet changes, medications, and other lifestyle changes to manage symptoms.
Irritable bowel syndrome (IBS) is a GI (gastrointestinal) disorder with signs and symptoms of:
Therefore, many doctors recommend a gradual reduction in dose when TCAs are discontinued.